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Accutane ruined my joints



  They also emphasized that all rheumatologic symptoms of the patients disappeared after the discontinuation of the drug and the complaints were drug related [ 2 ]. Provided by the Springer Nature SharedIt content-sharing initiative. I feel like killing myself every day, and keeping down a job is impossible.     ❾-50%}

 

Accutane ruined my joints



    I would take severe acne over a broken penis any day. Accepted : 18 September At the time, my testosterone was normal, a little lower than before Accutane. He ask me if i still have isotretinoim at home i said yes and he told me to finish taking all the pills i have now, i have to go back in April but i wont take the pills i have left i just will tell him that i did take them because he will give me a cream for my face when i go back in April. Shortly after taking accutane my face cleared up, my docs office was full of other docs wanting to see how amazing the guinea pigs face cleared up!

None of which had been an issue previously. After reading many different stories, articles, and literature about Accutane products I am leaning more toward the fact that this very well may be of my own doing by taking Clarivis. I remain positive and focused on making the most out of my sexual future however I can. Specifically what type of doctor you may have consulted first, PCP, or Gyn. I am 48 and took Accutane when I was 19 for a few years. About 10 years ago I noticed a lack of libido. I could not reach orgasm while masturbating.

I could not tell I was inside. At first I thought it was the girl until after a few other partners I realized I had the same results. I saw 5 different doctors and no one had a clue as to why I was having this issue.

My testosterone levels were low so I take Fortesta and use Viagra. It really is horrible. I came upon this thread while researching. I am in the same boat as all of you and have been searching for over 10 years how to reverse the lifelong effects of this poison. I was given 3 cycles from ages Overall skin is worse, prematurely aged me and ruined my body and life. Action needs to be taken against the company and doctors who give this poison to kids who just want clear skin and have no idea that it is going to rob them of their lives.

Im a person who took roaccuatane and I never linked severe abdominable pain to this drug. I was young naive and took it because of my skin doctor said so. I also got a racing heart condition which to this day is undiagnosed. My stomach pains were undiagnosed and i was also referred to a pysychiatrist as well. My family have thought i was mad most of my life since this drug also. I also get random sexual disfunction not always just sometimes which is annoying.

I have also always been passed over for promotion in my job all the time since roaccuatane. I went to doctor and he wanted me to wait a week more to get a medicine and picture for him to analyze more…. I also went to other doctor and he said probably im depressed without realizing it…however I also depressed after using it.

R, I could not understand exactly your instruction with the moringa drumstick tree. I am a female Accuatine taker and I shall to lower the dose and take the moringa or keep the libido damage to minimum…. I took accutane at ages 15, 17, and Every side effect you can basically list I have. Stunted growth extremely dry skin, joint pain, eczema, foggy brain, no muscle, attitude change no motivation, cant gain any weight, sexual dysfunction, hairloss etc..

Doctors and everyone else telling me there is nothing wrong and to just be patient. Well I got educated from research many years ago praying that something would cure us. Seems like this drug destroys cells along with your body with life long lasting side effects.

I have taken every supplement and other plans of actions to help without avail. If the doctor had told me this was designed as chemo drug and the side effects would be with you for the rest of our lives, then no way would i have taken it. Both doctors and roche are to blame for ever giving this to a kid who hasnt developed. They should have to use the billions a year they made off it to research a way to reverse it, if even possible.

Everyday above ground is still a blessing an many others have it worse, but you cant help but think how different your life might have been had you made better decisions in your younger years and that hurts every time.

Much greater awareness needs to be raised. Hi I took roacutane while i was Before then i was normal in every way. Since then i have had many serious gay thoughts. I have slept with many men as their girl. I have been bedded by many gay top men for just casual sex. I attribute this fascinatin with roacutane. I have never been cured and still sleep with men so they can have sex with me all the time.

I took Roacutane after i had many other prescriptions that didnt work well. It dried my skin and made me feel lethargic. My doctor said that was normal and would stop after a while at the end of the course of this treatment. Around 6 months after the treatment I noticed i wouldnt always get an erection. It was on and off and sometimes went small during the intercourse. My doctors could find nothing to indicate a problem so i have lived with it ever since.

Sometimes i cant and other times its very good. My normal actions are gone and replaced with irrational physical goings on. There is no cure. Dont take roacutane guys you will regret it. I was given this drug in for a few pimples. During the course I experienced low libido, genital numbness, joint and muscle pain, and dry lips. Five years later, all of these symptoms have worsened in addition to other symptoms that began one month after stopping treatment including digestive problems, dry and thin skin, dry hair, hair loss, tinnitus, muscle spasms, hand and feet numbness, chronic fatigue, memory loss, and an overall feeling of not being well.

Dermatologists need to be informed and not hand this stuff out like candy for mild to moderate acne. If they do, they need to warn the patients about the possible permanent side effects. I was told that none of the side effects were permanent, except if I became pregnant, there would be possible permanent damage to the fetus and I would have to get an abortion.

The permanent side effects are definitely not worth the risk. Hello, I am a 20 year old male from the United Kingdom. In , I decided to give roaccutane a try for my treatment-resistant acne. The acne was not cystic, but it did not respond to antibiotics. Before seeing a dermatologist, I did a lot of research into roaccutane and decided that the benefits outweighed the risks.

Little did I know, I was about to make a very big mistake. As a precaution, I only took roaccutane for a short amount Of time 1 month coursemg per day. By taking it for a short amount of time, I thought I would be avoiding long term side effects. How wrong was I. Towards the 4th week of my course, I started to notice I was depressed, and my sex drive was greatly diminished, and found it difficult to achieve an erection even with a hot girl.

I thought these effects would be temporary, but I stopped taking it just in case. And to my absolute horror, the side effects persisted. However when I do eventually get an erection, I find it difficult to reach orgasm. I have also noticed a decrease in my ejaculatory volume. Having depression is one thing, but having a dick that hardly works is just ridiculous.

To combat these effects, I have tried a combination of supplements and have had some improvement. If anybody would like to talk about this issue, I would be happy to do so.

You can email me: henthornedward yahoo. Some days, I have been very close to ending all this bullshit. For the past 9 months, I have literally been hanging on by a thread. The amount of misery this drug has caused me is hard to put into words, but hopefully together we will find some way to get through this.

Hi Ed. Until post-Accutane sufferers have a proper forum, this seems the best place to gather to discuss finding ways out of this. I only took roaccutane isotretinoin for 1 month. No one would usually bother to read the journal references the author included, and so they add an air of legitimacy to the article that is not contrived. If you do bother to read the supplied articles, you will see that there are two cases of sexual dysfunction associated with Accutane among females reported, and a few more cases of erectile dysfunction.

The odds are overwhelming that these effects have nothing to do with Accutane, given that sexual dysfunction affects a huge subset of the population minus medication.

These numbers are so minuscule, and the results have not been replicated properly, and this drug has been on the market for some time now. There are more risks in taking long-term minocycline antibiotic than Accutane, which most GPs have no problem prescribing to teenagers and young adults for mild acne and virtually no one criticizes GPs for this. In sum, sensationalism is fueling the media reports on Accutane rather than evidence-based science.

Even some GPs are fooled my the nonsense that is heralded in innumerable media stories——either that, or they are afraid of law-suits based on a few testimonial reports rather than real data.

This response sounds very like Formerly 98, John Alan Tucker. He has also edited out of existence almost any reference on Wikipedia to the side effects of drugs like the Fluoroquinolones and Olanzapine. While there is an appeal here to science and controlled trials, the likely driver in Formerly 98s case and perhaps jdlkmabc may be something much more anecdotal — perhaps a sexual difficulty at some point earlier in life — from which a conclusion has been drawn that all that is involved with SSRIs, Finasteride, or Accutane is what happened to him.

Anyone can have sexual difficuties — this is true. But these difficulties are rarely accompanied by profound genital anesthesia — whereas SSRIs for instance produce very clearly and demonstrate genital anesthesia within 30 minutes of having one and this provides the basis for their marketing authorisation for premature ejaculation. Accutane is also a serotonin reuptake inhibitor.

To assume that trials always pick up on every side effect a drug has, is incorrect. I can personally assure you, that this drug causes sexual dysfunction. You only need to look at other 5 alpha reductase inhibitors such as Finasteride. Studies on this drug clearly demonstrate that it can have lasting effects on users, it has been shown to effect protein expression in the Nucleus Accumbens, an area highly involved in pleasure.

Now if this drug which works as a 5 alpha reductase inhibitor can do this, its not too hard to believe that its plausible, that Accutane, a known potent 5 alpha reductase inhibitor can have similar effects. Sexual Dysfunction is common, this is true, but sexual dysfunction lasting years is not.

I have experienced sexual dysfunction for the last 10 years. Trust me that, persistent sexual dysfunction is different to sexual dysfunction.

No amount of sex therapy is going to fix this. But I implore you to give this medication to your teenage son and daughter, and we can see if after 6 months, you still hold the same viewpoint.

So on one hand we have a lot of people informally reporting the same effects on their body all having taken Accutane or a generic form. On the other hand we have very few scientific studies to support the link between the two.

Could the fact that there are few studies supporting this be because there are few people willing to study it for fear they might find out the truth? Went on Roaccutane over 20 years ago for about a year. I was completely normal one minute and not the next-major extreme in difference.

Normal libido and orgasmic before the drug to low libido and never orgasming again. I thought something seriously got damaged with my privates or something.

Every doctor i went to said its all in your head blah blah blah but i knew it was total rubbish. Its only the last year from watching a tv program about others having the same symptoms that the lightbulb totally went off that it was the drug that did this to me as the timeline from when it started happening is smack on.

I would love a cure. Only people that have this understand. The people that say there is no proof that this drug did this would think differently if it happened to them.

Antecedent: I was only 18 when I have become it: I had a beautiful girlfriend, I was very happy -my libido—oh my God…! After Roaccutane: But I had very-very acute Acne conglobata…. I became Roaccutane two times, 2 courses — this was terrible, my father — I remember, asked me — what is this? My libido: After the second time I become Roaccutane- I fell to the other side of the horse.. My girlfried had done with me…!!! It was off! This is not only a Vit-A version.

Forgetting viagra and ciallis, others? Take accutane, clears skins, but kills your sex life. Not to take accutane, grotesque skin, puts people off, also kills your sex life. Um, are you joking? Clearly not to take. Told no permanent side-effects. Was healthy and extremely energetic prior to Accutane. Family has no medical issues too.

Once I started Accutane I got: Depression face dryness Facial coldsores or the like lack of libido nose bleeds. I was only young at the time. Now I think to myself this: how can the drug permanently get rid of the acne without permanent side-effects? You are in a small concrete room with only one opening. In this opening your food, oxygen and many other things you need appear.

You are very happy aside from the fact that mosquitos also enter from this opening. They bite you every night…all night. You use the telephone next to the opening to call for help on this matter one day. He provides you with the bricks, which he places in the opening, one brick per day as well as temporary air cylinders and food packages. After some time the wall is nearly up and you are happy the mosquitos have dwindled in number. You place the final brick and the mosquitos stop.

You are extremely happy and are now just waiting for the oxygen, food and other benefits to return. You gasp for air as you start banging on the wall in an attempt to break it but your hands are too soft… You call the operator and ask for a hammer but he says the opening is now closed and he does not know how to send one to you. What is abundantly clear to me now is that my acne has never come back which means these side-effects will never go away either. Some successes I have had no permanent relief just temporary bandaid solutions ; Burning the veins within the nose to reduce nose bleeds not allowing them to dry out.

Taking Viagra has helped increase the strength of erection slightly…enough to allow for penetration. I would like to say for all those people who say this is all in our heads. Maybe one or two of the symptoms might not be related but to go from a perfectly healthy person to a person with over 25 ailments in the space of one year is not normal. To go from being able to memorise complete essays word for word to not being able to remember where I put the keys 5 mins ago, all the time, is not normal.

One day I hope that the company will be made to pay… I am sure if we all get together we could make a class law suit… thousands of people with similar permanent side-effects which were supposed to be temporary is too much to brush off as coincidence.

Finally on a note of hope. Even with all this side-effects I am still trying to move on with my life. I exercise whenever I can as that improves my mood and my body. I keep thinking how other healthy people have it much worse and are being killed every day and starve to death.

The Viagra also helps. It is not a complete fix but even that small amount that it helps gives me some happiness. For those others out there who are finding it hard to cope just keep remembering that there is always someone else who has it worse off than you and has the courage to continue. Find hobbies and things that interest you and pursue those. I have learnt not to care about what other people think and to do things which make me happy. I have pressure at home because I struggle at university due to the side-effects.

Mainly anxiety. They want me to get married have children and get a good job my family is well-off and hard-working but I feel place too much emphasis on money and looks. Once I finish, if it is in gods will, I will be moving overseas, possibly to China, to live a life how I want to. I will find a modest job and just enjoy every day doing what I want to when I want to.

I will stay in contact with my family but i will live my life how I want by making money to live not living to make money. I am gratefull my joint pains and back pains have been slowly improving with exercise. I anticipate my body should hold up relatively well until I am at least This gives me over 20 years to enjoy myself, meet new people and just live. If I meet a women who understands me and loves me for me then maybe i will find love. I should also note that I am gratefull for the 16 years of life which I thoroughly enjoyed and lived to the fullest prior to Accutane.

Good luck to everyone, keep your chins up and just plodding along.. Hi mate are u from the uk? I was on Accutane at 16 years. Erectile dysfunction and hormonal Problems the worst of all. Another Problem of us is the ignorance of the doctors, they say its in your head Fucking bullshit. The doctors and drug companies are working together. I was given this drug in when it first came out at that time they knew it caused sterility in male dogs but told no one, now at 40 my testosterone levels should be around to instead its and I am completely sterile after many genetic tests no genetic cause for this was found, no one in my family on either side back four generations had any of these problems.

Clear skin was not worth losing the ability to someday be a father! Accutane destroyed my sex drive. The worse mistake I ever made. My acne did go away — not completely, but it did prove to be very efficient after a little over than 6 months.

Regardless, it was not worth it. The decision is yours to make, sure, but at least mark my words, and let them have an influence on your choice. Anyone else ever order viagra or any erection drugs online with any good results?

Thomas, I would try herbal supplements, L-Arginine and Niacin to help improve blood flow. But they do require a prescription so it is legitimate and safe. If you really want Viagra I would explain your situation to a doctor, write down your side effects if necessary or print out a study, and they should be able to give this to you. I have post finasteride syndrome ongoing side effects from taking the hair loss drug propecia since and it has been life changing, physically, sexually, cognitively.

Your physical, sexual, mentla health should come first before clear skin or a full head of hair. These medications affect everyone differently, but the potential they have to change your body is scary and not in the marketing campaigns.

I was prescribed accutane a number of years ago as i had very bad acne and I had a lot of the problems peoples have described here. I am now going to celebrate my 40th birthday this March so it was a while ago. I was prescribed accutane twice the first time i was on it for several months and it nearly ruined my relationship but I had a understanding girlfriend and i am glad to say we have been married for nearly 6 years.

The second time i was prescribed accutane I stopped taking it after two weeks. I have been diagnosed with bowel disease, suffer depression, impotence and have been unable conceive children, losing my hair and ruined my relationship with my brother and sister. The worst thing is that my acne was a side effect of another condition i have. It appears that the dermatologist was treating the symptoms and not the cause of my acne.

Please note my next comment do not apply to everyone and so should not be taken literally as these are my experiences from my journey. I stopped taking accutane after two weeks of my second dose as I was diagnosed with acromegaly which is a hormonal condition after i had a operation to help resolve my acromegaly my acne cleared up overnight.

I now live an acne free life but have to live with, in my opinion the side effects of accutane of which i should never have been prescribed in the first place. I have a beautiful loving wife and continue to try to build my relationships with both my brother and sister, My acromegaly is an on going problem but i am one of the lucky ones even with the problems i continue to live with.

Roaccutane Action Group, committed suicide last month after 21 long years of suffering severe depression and painful physical complications brought about by Accutane. I never knew him personally, but Mr.

Chow contributed a great deal to those of us left with long-term side effects from Accutane. Very sad to read the forwarded message. What did Roche have to say about this case? Hard to believe that when I see how many comments have been received here and the severity of their cases. Ruined my sex life. I have to use plenty lub. Hopefully it subsides. This is the worst ever.

Acne gone but sex life gone. I pray my life comes back together again. I took Accutane 22 years ago. My first attempt at intercourse was 3 weeks into it, and it was a failure that left me without confidence which I have never recovered from. I have suffered greatly mentally, with no confidence in my sexual ability. That being said, here are some things that give me hope:. If I take Viagra, and continue to have sex daily, I can go for several days without the need for another pill.

Trying to be positive, I have a possible theory: It may be that I overindulged in masturbation as a teen, and people who do that may be prone to have acne. Also, being almost 40 years old, I have no idea what to expect as far as functioning is concerned. I noticed while on the treatment that I was not as horny as I had been. I would see girls that I had previously found super attractive and noticed I was not having as strong of a mental response to seeing them.

I thought my sex drive was an unbreakable constant in my life and that losing it was something that only happened to old guys with low t. I have almost zero sexual interest, I want to want to have sex, if that makes any sense.

If I see a girl or an image of a girl that would have in the past mentally aroused me, I feel absolutely nothing. I might as well be looking at a rock or a tree. With the libido and arousal problems I also have pretty bad erectile dysfunction.

Luckily orgasms are still pleasurable to a decent degree for me. I can masturbate, however I also suffer from the same difficulties with this as with sex.

Recently I was approached by a kid on my floor at college who tells me he has the exact same problems. He took accutane longer than me and at a higher dose, and his problems are more severe. He has no libido and says its almost impossible for him to masturbate to completion. I never had sex before taking this drug, if you are reading this and are considering taking this drug, I would highly suggest that you reconsider because it may be the worst decision you have ever made in your life.

My dysfunction is the first thing on my mind when I wake up and the last on my mind when I go to sleep. My advice, stop caring about your skin and learn to love yourself for who you are.

I am a physician and took isotretinion for about two months, about two years ago. I had loss of libidos and impotence about five weeks after starting it. I have been digging deep into research papers to figure out what the if anything can help it. It seems that this drug reduces the ability of the body to convert testosterone into dihydrotestosterone DHT.

DHT is the hormone that is deficient in men and women and needs to be replaced to get back your libido and improve depression. While taking testosterone will help, taking androgenic steroids such as mesterolone which is analog o DHT will make you feel almost back up your old self. Ideally, taking mg of testosterone and mg of Mesterolone commonly known as Masteron subcutaneously will help significantly. Women have to be more careful about the dose as they will have irreversible masculinization if the dose is too high.

When a patient with acne develops depression, dermatologists take this seriously. They are trained to spot warning signs that a patient could be depressed. Before prescribing isotretinoin, dermatologists also screen patients carefully for possible signs of depression and thoughts of suicide. This helps them determine if the medication is a good option for you.

Researchers have also studied the connection between acne and IBD. While some studies suggest that taking isotretinoin may increase the risk of developing IBD, other studies have not found this to be true. To find out whether this medication can cause IBD, researchers continue to study this possible side effect.

This research takes time. Researchers have to account for many considerations. For example, it's possible that the genes which increase your risk of having severe acne also increase your risk of developing IBD. Before prescribing isotretinoin, your dermatologist will talk with you about your acne and give you information about isotretinoin.

This can help you decide whether this medication is right for you. If you and your dermatologist decide that isotretinoin is the right treatment, your dermatologist will watch for warning signs of side effects. You will meet with your dermatologist every 30 days, either in-person or through telemedicine. If all is well, your dermatologist can write another day prescription for isotretinoin.

Writing a new prescription every 30 days is a safeguard that helps protect your health. In the United States, a doctor can only prescribe isotretinoin for 30 days. To get another prescription, you need to check in with your dermatologist. During your check-ins, tell your dermatologist how you feel, even if it seems unrelated to taking isotretinoin. Acne can affect more than your skin. Isotretinoin: Overview. Moisturizer: Why you may need it if you have acne. People taking Accutane should see a doctor if any of the minor side effects persist and are causing them difficulty.

If anyone notices these symptoms while taking Accutane, they should stop taking the medication immediately and call a doctor. Also, anyone who breaks a bone should tell the doctor treating them that they are taking Accutane.

Accutane is an effective treatment for severe acne, but it has some serious side effects, including mental health problems and risks associated with pregnancy. Anyone who is considering taking this medication should have a detailed conversation with their doctor about the risks and how to reduce them. Accutane, a drug that helps treat severe acne, contains isotretinoin.

Isotretinoin may cause side effects, including hair loss. Learn more about why…. Salicylic acid and benzoyl peroxide are two common ingredients in acne medications.

Learn about the benefits and side effects of each here. Cystic acne is an uncommon and severe form of acne. The skin condition results from blocked pores in the skin that cause infection and inflammation…. Back acne, or backne, is a common condition that occurs when oil and skin cells block pores. Learn about its treatment and prevention here. The amazing story of hepatitis C, from discovery to cure New directions in dementia research Can psychedelics rewire a depressed, anxious brain?

Medical News Today. Health Conditions Discover Tools Connect. What are the side effects of Accutane? Side effects Long-term After stopping Interactions Seeing a doctor Summary Isotretinoin Accutane is a medication that doctors prescribe to treat severe acne. In each region, each type of lesion is given a number: zero for no lesion, one for comedones, two for papules, three for pustules and four for nodules. It was investigated that whether there was a enthesitis by a detailed clinical examination.

The following entheses were examined for tenderness and swelling bilaterally: common extensor tendon insertion on the lateral epicondyle of the humerus, quadriceps tendon, patellar tendon, tibial tuberosity, knee medial collateral ligament, Achilles tendon, and plantar fascia insertion on the calcaneus [ 23 ]. If there was a swelling and erythema, it was considered as inflammatory enthesitis.

The absence of swelling or erythema was considered to be mechanical enthesitis. The ASAS criteria consist of commencement under the age of 40, insidious onset, relief with exercise, no relief with rest and nocturnal pain improving with rising up from bed. These 4 items are essential in diagnosing inflammatory low back pain. The various imaging modalities, including conventional radiography, computed tomography CT , magnetic resonance imaging MRI and bone scintigraphy are used for investigation of inflammatory changes at the sacroiliac joints.

In early and acute stages of sacroiliitis the diagnosis can be difficult because conventional radiographs may be normal. Inflammatory back pain is not a specific indicator of sacroiliitis. Therefore, there is need for valuable imaging methods. Scintigraphy lacks specificity.

CT is a very good method for visualization of established bony destruction or ossification. MRI can identify both inflammation and structural changes, localise different degrees of inflammation and bone marrow edema, and differentiate a possible septic sacroiliitis. MRI is the most sensitive and specific modality for sacroiliitis by directly imaging changes in the synovium, articular cartilage, and subchondral bone [ 26 , 27 , 28 ].

In our study, the patients meeting ASAS criteria for inflammatory back pain were evaluated in detail and requested both sacroiliac radiography and sacroiliac MRI. Sacroiliac MRI was performed on 1. At least 12 slices of coronal oblique T1-weighted turbo spin-echo and short tau inversion recovery STIR sequences of the sacroiliac joints were acquired. This images were interpreted by the same reader who had received standardized training and were blinded with regard to the study groups.

In addition, laboratory blood tests including rheumatoid factor RF , erythrocyte sedimentation rate ESR and c-reactive protein CRP values were requested. Anti-nuclear antibody ANA was ordered to rule out other connective tissue diseases. Data were analyzed using SPSS software version The normality of the data was tested by Kolmogorov-Smirnov test.

For the comparison of the paired groups, the independent samples t-test normal distribution and the Mann-Whitney U test non-normal distribution were used for the quantitative data.

Chi-squared test was used to evaluate whether there was a difference in terms of musculoskeletal symptoms between the study groups. This case-control study included 94 71 women, 23 men patients with acne vulgaris receiving isotretinoin and 74 women, 26 men age- and sex-matched controls.

The age and sex distributions of the study and control groups are presented in Table 1. All of the tendinopathies were mechanical feature, swelling or erythema was not observed. The flow chart of the participants was presented in Fig. The median duration of treatment was 3 min. There was a total of 66 patients The clinical characteristics of both isotretinoin group and healthy controls can be seen in Table 2. The median duration of treatment was 3 IQR: 3, min. The comparison of the patients who had musculoskeletal symptoms or not in isotretinoin group regarding as total cumulative dose of drug were given in Table 3.

The results of linear regression analysis between the age, sex, duration of treatment and cumulative dose of drug with musculoskeletal side effects were shown in Table 4. The sacroiliac radiography was normal in all of the patients with inflammatory back pain. In sacroiliac MRI, sacroiliitis was observed in 11 Semicoronal short tau inversion recovery STIR images show hyperintense lesions arrows consistent with bone marrow edema in bilateral sacroiliac joints.

Semicoronal T1-weighted spin-echo image shows signal loss arrows in sacroiliac joints consistent with sacroiliitis. The patients who developed rheumatologic symptoms during isotretinoin usage were called to follow-ups by monthly. They were evaluated by a specialist and physical examination was performed at each time they came to control. VAS scores of the patients were also assessed at each follow-up.

In addition, routine biochemical blood tests were acquired from all of the patients in isotretinoin group. The patients who developed musculoskeletal symptoms such as mechanical back pain, arthralgia, myalgia or tendinopathy, except for sacroiliitis were initiated a nonsteroidal antiinflammatory drugs NSAID and continued a lower dose of isotretinoin. In patients who were diagnosed as sacroiliitis, the drug was discontinued immediately and a NSAID was prescribed.

We observed that the complaints of these patients were resolved within a month after cessation of the drug and VAS scores were also decreased dramatically. The symptoms were mostly disappeared by the third month. All the patients with sacroiliitis were completely symptom free at the sixth month of the discontinuation of the drug. Isotretinoin, or cis retinoic acid, is a vitamin A derivative used for severe recalcitrant acne since Although isotretinoin is a very effective drug, it may have many side effects.

It is essential that the clinician should be careful about the various side effects of the drug [ 30 ]. In this study, we focused on the musculoskeletal side effects of isotretinoin. Ninety-four patients treated with isotretinoin suffering from musculoskeletal pain were included. The patients were then examined in detail. They were also compared with healthy controls. Isotretinoin has been associated with various musculoskeletal side effects in the recent literature.

Some of these are original studies, while most of them are sporadic case reports [ 1 , 2 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. The onset of the musculoskeletal symptoms of the patients in these case reports was in the first few months.

They have found myalgia in Acute sacroiliitis was determined in 8. The authors concluded that the incidence of sacroiliitis in patients receiving isotretinoin is quite high [ 1 ]. In our study, the percentages of myalgia and sacroiliitis were similar to this study, however, the frequency of back pain was noticeably higher in isotretinoin group.

This was one of the most important results of this study. Other musculoskeletal side effects were not found to be statistically significantly related with the total cumulative dose of isotretinoin.

The patients with low back pain using isotretinoin should be asked about the dosage and duration of their drug, and if necessary, the dose should be reduced. On the other hand, it is an interesting finding that sacroiliitis is not related with the total cumulative dose of the drug. In their study, Alkan et al. In the isotretinoin group, No inflammatory back pain was observed in tetracycline group 32 patients.

They found unilateral sacroiliitis only in one patient in the isotretinoin group that included a total of 42 patients. They also emphasized that all rheumatologic symptoms of the patients disappeared after the discontinuation of the drug and the complaints were drug related [ 2 ]. In the present study,

Metrics details. Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit. Isotretinoin is an effective treatment option for severe acne. The aim of this study was to evaluate musculoskeletal side effects of systemic isotretinoin treatment. Ninety-four patients with acne vulgaris and sex- and age-matched controls were enrolled in this study. Only the patients who had musculoskeletal symptoms were evaluated in this study.

All participants were firstly assessed by a dermatologist. The patients were asked whether they had any musculoskeletal symptoms after isotretinoin treatment, if so, the feature and duration of the symptoms were recorded. The dosage of the drug, treatment duration, incidence of arthralgia, myalgia, low back pain, sacroiliitis and tendinopathy and laboratory test results were noted.

The severity of pain was assessed by visual analog scale VAS. Of the 94 patients, 71 were female and 23 were male. Bone marrow edema consistent with sacroiliitis was detected by sacroiliac MRI in 11 patients with inflammatory back pain.

Low back pain is one of the very common complications of isotretinoin. It can be mostly mechanical or inflammatory. Isotretinoin-induced low back pain is dose-related, and inflammatory back pain without sacroiliitis is also frequent. The clinicians should be aware of the back pain may be a reflective of sacroiliitis during isotretinoin usage.

Peer Review reports. Acne vulgaris is a chronic inflammatory disease affecting the pilosebaceous unit with multifactorial etiology [ 1 ]. Isotretinoin is an effective treatment option for severe acne vulgaris. Isotretinoin has a wide spectrum of side effects, including multiorgan systems such as reproductive, mucocutaneous, ocular, neurological, musculoskeletal and hepatic systems. It may also cause several musculoskeletal side effects such as arthralgia, myalgia, back pain, spondyloarthropathy-related symptoms and sacroiliitis [ 123 ].

Other uncommon musculoskeletal disorders related with isotretinoin are hyperostosis, extraspinal calcifications, enthesitis, arthritis, costochondritis, osteoporosis, growth retardation, premature epiphyseal closure in children and as well as gout [ 3678 ].

In the literature, there are only a few original studies investigating the musculoskeletal side effects of isotretinoin [ 12910 ]. Furthermore, there are many case reports or case series indicating the musculoskeletal side effects of isotretinoin [ 11121314151617181920 ].

The majority of the recently performed studies are the case studies regarding with isotretinoin-induced sacroiliitis [ 1113161820 ]. To the best our knowledge, there is no controlled study investigating the presence of isotretinoin-related musculoskeletal side effects with a wide spectrum such as arthralgia, myalgia, low back pain, sacroiliitis, tendinopathy and enthesopathy.

In previous studies, the incidence of sacroiliitis and back pain were the most detected parameters [ 1210 ]. The primary aim of this study was to evaluate and emphasize the musculoskeletal side effects of systemic isotretinoin treatment in patients with acne vulgaris and to compare them with healthy controls.

The second aim was to elucidate clinicians regarding with isotretinoin-induced musculoskeletal symptoms. A total of 94 patients with moderate to severe acne vulgaris treated with systemic isotretinoin and sex- and age-matched controls who were admitted to Ankara Training and Research Hospital, Department of Dermatology, between September and April were enrolled in this cross-sectional study. The local ethics committee approved the study.

All participants were informed about the study and their written consent form was obtained. Isotretinoin group included the patients under isotretinoin treatment for acne vulgaris, but had no history of rheumatologic syndromes.

The control group was selected from among health professionals who had received a routine medical checkup in the hospital. Exclusion criteria for this study were the presence of any chronic rheumatological, dermatological diseases or any patients with a history of mechanical back pain, inflammatory back pain, sacroiliitis, enthesitis, before starting isotretinoin, history suggestive of spondyloarthropathies reactive arthritis, ankylosing spondylitis, inflammatory bowel disease, and psoriasisor systemic autoimmune disorders.

Also, the patients with depression or similar psychiatric diseases, had renal and liver function disorders, those who were pregnant or using any systemic drugs for other diseases, were not included. All participants were firstly evaluated by a dermatologist and questioned carefully about the musculoskeletal symptoms. Only the patients who had musculoskeletal symptoms such as myalgia, arthralgia, back pain were determined and enrolled in the study.

They were referred to the physical medicine and rehabilitation department and examined by a specialist. Sociodemographic information, including age, sex, history of drug use dose and durationhistory of chronic diseases were recorded. A detailed anamnesis was obtained and a careful dermatological and physical examination was performed by both of the specialists. It was queried that whether myalgia, arthralgia and low back pain occurred after starting isotretinoin treatment.

Data were recorded on a standardized pre-prepared evaluation form. The pain severity of the participants was evaluated by visual analog scale VAS based on a chart numbered from 0 no symptom to 10 maximum severity. According to GAGS, the body was divided into six regions -forehead, nose, each cheek, chin and back. In each region, each type of lesion is given a number: zero for no lesion, one for comedones, two for papules, three for pustules and four for nodules.

It was investigated that whether there was a enthesitis by a detailed clinical examination. The following entheses were examined for tenderness and swelling bilaterally: common extensor tendon insertion on the lateral epicondyle of the humerus, quadriceps tendon, patellar tendon, tibial tuberosity, knee medial collateral ligament, Achilles tendon, and plantar fascia insertion on the calcaneus [ 23 ].

If there was a swelling and erythema, it was considered as inflammatory enthesitis. The absence of swelling or erythema was considered to be mechanical enthesitis. The ASAS criteria consist of commencement under the age of 40, insidious onset, relief with exercise, no relief with rest and nocturnal pain improving with rising up from bed. These 4 items are essential in diagnosing inflammatory low back pain. The various imaging modalities, including conventional radiography, computed tomography CTmagnetic resonance imaging MRI and bone scintigraphy are used for investigation of inflammatory changes at the sacroiliac joints.

In early and acute stages of sacroiliitis the diagnosis can be difficult because conventional radiographs may be normal. Inflammatory back pain is not a specific indicator of sacroiliitis. Therefore, there is need for valuable imaging methods. Scintigraphy lacks specificity. CT is a very good method for visualization of established bony destruction or ossification.

MRI can identify both inflammation and structural changes, localise different degrees of inflammation and bone marrow edema, and differentiate a possible septic sacroiliitis. MRI is the most sensitive and specific modality for sacroiliitis by directly imaging changes in the synovium, articular cartilage, and subchondral bone [ 262728 ]. In our study, the patients meeting ASAS criteria for inflammatory back pain were evaluated in detail and requested both sacroiliac radiography and sacroiliac MRI.

Sacroiliac MRI was performed on 1. At least 12 slices of coronal oblique T1-weighted turbo spin-echo and short tau inversion recovery STIR sequences of the sacroiliac joints were acquired. This images were interpreted by the same reader who had received standardized training and were blinded with regard to the study groups.

In addition, laboratory blood tests including rheumatoid factor RFerythrocyte sedimentation rate ESR and c-reactive protein CRP values were requested. Anti-nuclear antibody ANA was ordered to rule out other connective tissue diseases. Data were analyzed using SPSS software version The normality of the data was tested by Kolmogorov-Smirnov test. For the comparison of the paired groups, the independent samples t-test normal distribution and the Mann-Whitney U test non-normal distribution were used for the quantitative data.

Chi-squared test was used to evaluate whether there was a difference in terms of musculoskeletal symptoms between the study groups.

This case-control study included 94 71 women, 23 men patients with acne vulgaris receiving isotretinoin and 74 women, 26 men age- and sex-matched controls. The age and sex distributions of the study and control groups are presented in Table 1. All of the tendinopathies were mechanical feature, swelling or erythema was not observed.

The flow chart of the participants was presented in Fig. The median duration of treatment was 3 min. There was a total of 66 patients The clinical characteristics of both isotretinoin group and healthy controls can be seen in Table 2.

The median duration of treatment was 3 IQR: 3, min. The comparison of the patients who had musculoskeletal symptoms or not in isotretinoin group regarding as total cumulative dose of drug were given in Table 3. The results of linear regression analysis between the age, sex, duration of treatment and cumulative dose of drug with musculoskeletal side effects were shown in Table 4.

The sacroiliac radiography was normal in all of the patients with inflammatory back pain. In sacroiliac MRI, sacroiliitis was observed in 11 Semicoronal short tau inversion recovery STIR images show hyperintense lesions arrows consistent with bone marrow edema in bilateral sacroiliac joints.

Semicoronal T1-weighted spin-echo image shows signal loss arrows in sacroiliac joints consistent with sacroiliitis. The patients who developed rheumatologic symptoms during isotretinoin usage were called to follow-ups by monthly. They were evaluated by a specialist and physical examination was performed at each time they came to control. VAS scores of the patients were also assessed at each follow-up. In addition, routine biochemical blood tests were acquired from all of the patients in isotretinoin group.

The patients who developed musculoskeletal symptoms such as mechanical back pain, arthralgia, myalgia or tendinopathy, except for sacroiliitis were initiated a nonsteroidal antiinflammatory drugs NSAID and continued a lower dose of isotretinoin. In patients who were diagnosed as sacroiliitis, the drug was discontinued immediately and a NSAID was prescribed. We observed that the complaints of these patients were resolved within a month after cessation of the drug and VAS scores were also decreased dramatically.

The symptoms were mostly disappeared by the third month. All the patients with sacroiliitis were completely symptom free at the sixth month of the discontinuation of the drug. Isotretinoin, or cis retinoic acid, is a vitamin A derivative used for severe recalcitrant acne since Although isotretinoin is a very effective drug, it may have many side effects. It is essential that the clinician should be careful about the various side effects of the drug [ 30 ].

In this study, we focused on the musculoskeletal side effects of isotretinoin. Ninety-four patients treated with isotretinoin suffering from musculoskeletal pain were included. The patients were then examined in detail.

localhost › health › acne › accutane. Isotretinoin can cause pain in your bones, joints, muscles, and ligaments. It can also stunt the growth of long bones in teens, which could have permanent. Common side effects of Accutane include joint pain, If your side effects last more than a few weeks after you stop taking isotretinoin. The severity of pain was assessed by visual analog scale (VAS). The severity of acne vulgaris was evaluated by Global Acne Grading Scale. joints. People should discuss any exercise they do with their doctor before starting this drug. Accutane may stop long bone growth in teenagers. Share this article. I am a 28 year old man. Although sacroiliitis is a rare complication of isotretinoin, inflammatory back pain without sacroiliitis can be seen frequently. The pain was unbearable sometimes but is non existent away in the summers. I even became a single mother and it is not confirmed that that is why but I am almost positive it has a lot to do with why he even left me. So it certainly looks like back pain is possible, although whether delayed like this is less clear to me. Simply suing them is not enough.

There are an ever-increasing and disturbing number of young people claiming their sex lives have been permanently ruined from taking the acne drug, isotretinoin , commonly referred to by its former brand-name, Accutane. Often these affected young men and women, many in their teens and early 20s, cannot overcome their embarrassment to report sexual side effects while taking the drug.

Or they continue to expect those side effects to abate after cessation of the drug. Sometimes, they discontinue isotretinoin early because of sexual problems only to find that the problems get worse and persist indefinitely after taking the last pill.

Sexual dysfunction has been my lot in life since taking Accutane over 14 years ago, and as noted, I am far from alone.

After going on treatment many people get mild-to-debilitating anhedonia, anxiety and fatigue. The sexual symptoms may initially be relatively mild. The problem can then significantly and rapidly worsen when isotretinoin is stopped.

Others have noted that it gets gradually worse on treatment and then continues to worsen when treatment is stopped. Our symptoms are typically treatment resistant. While some have noted a remission of symptoms over time, most have been left fruitlessly attempting symptom management for years. The sexual symptoms which occur as a result of isotretinoin in men include erectile dysfunction, impotence, partial or complete loss of libido, genital anesthesia, anorgasmia, decreased and watery ejaculate, shrinkage in the flaccid state and lack of blood flow to the glans when erect.

Women have reported vaginal dryness, painful intercourse, loss of libido, genital anesthesia, and anorgasmia as a result of isotretinoin treatment, any of which may accompany altered menses, loss of menstruation and infertility. Visits to the doctor can become a battle of wills when a generally healthy looking young person walks through the door complaining of erectile dysfunction or other sexual symptoms.

Many of us face difficulty when we try to implicate a drug we are no longer taking as the cause of our continued sexual dysfunction. In the event that a conventional test for hypogonadism is conducted, results typically fall within the normal reference range.

Male sufferers of our condition will often be told by endocrinologists that their testosterone is a little low for their age but is not low enough to warrant treatment. Even for those who have discovered hormonal imbalances after seeking medical attention, hormone replacement therapy HRT has done little to provide adequate symptom relief, even under the care of doctors whose specialty is HRT.

A study published in the November-December Spanish Urological Journal suggests that sexual adverse reactions are far more prevalent than what one would assume by viewing FDA statistics or browsing anecdotal reports on internet forums 1. Unless the methodology in the study was extremely flawed, this is clear evidence of a correlation between isotretinoin and both erectile dysfunction and depression.

Has this study been ignored by those whose job it is to protect or at least inform the public of such a deleterious effect of this prescription drug? The majority of affected men state a complete loss or significant decrease in morning and nocturnal erections. In a case report concerning a similar drug, acitretin, a 39 year old patient with no depressive symptoms reported experiencing erectile dysfunction while undergoing treatment.

The patient recovered after stopping treatment and refused a rechallenge 2. The authors cited several cases where erectile dysfunction occurred independently of depression during retinoid therapy and suggested that erectile dysfunction may be a side effect of the entire retinoid class of drugs, to which isotretinoin belongs.

Importantly, the authors also commented on the general unwillingness of patients to report erectile dysfunction. This year, a case of a 20 year old developing gynecomastia related to isotretinoin treatment was reported 3. The authors noted three similar case reports and suggested this could be due to a decrease in the effects of testosterone caused by the drug. Studies demonstrate that isotretinoin significantly disrupts normal endocrine function. IGF-1, pituitary hormones, 5-alpha and 3-alpha reduced steroids, and androgen receptor levels have been observed to be significantly decreased in patients as a result of isotretinoin treatment.

Hormonal antagonism elicited by isotretinoin is considered to be one of the ways it helps in acne. Hormonal antagonism is also believed by many in our patient group to be a likely explanation of the sexual side effects they experienced as a result of taking this drug. A medical hypothesis published in proposed that long-term side effects associated with isotretinoin, including erectile dysfunction, may be the end result of persistent modifications to mechanisms which control gene expression 4.

If true, this would indeed explain the enduring nature of sexual symptoms which emerged during isotretinoin treatment. Could the perceived shame and dread about future prospects for relationships and families brought about by sexual side effects be one of the determining factors in the reported cases of Accutane suicides?

I used to have to try and stop myself from thinking about girls all of the time; now, I could hardly care less. It is common knowledge that isotretinoin is prescribed for off-label use by dermatologists to treat mild to moderate acne, a use for which it is explicitly not intended for. Isotretinoin is a curse disguised as a blessing to the minority of us who suffer severely after ingesting the drug. For those of us with sexual dysfunction, our scars are much deeper than our acne would have ever caused.

To date, no direct link between isotretinoin and these side effects has been proven, but anecdotal evidence and existing studies point to a need for confirmation of what too many of us have experienced.

Very appropriate article. If you like sex even a little bit, know that that enjoyment could all be taken from you if you take Accutane.

Sexual dysfunction is pure hell. This warning absolutely needs to be added to the paragraph of side effects on the label. People need to know that this is a possibility.

Beforehand, I can say that I have that extreme libido, I am thinking of myself as a maniac but recently I am noticing myself as a blunt person. I am experiencing erection but its not lasting. I have the desire but my body is not responding. I wanna masturbate but my thing is just that flaccid. Is the problem gone after a while? Had loss of libido as well. Please note that I also posted blood test results, and I will do a spermogram to evaluate my condition.

Also recommend visiting the endocrinologist to do all these blood tests… dermatologists are useless in this regard. And the urologist to do more exams. You must state for the attention of the Isotretinoin EWG and ask that you be listed as a stakeholder and that you be kept updated.

Please outline all your concerns. They are mostly considering sexual dysfunction, infertility and psychiatric issues including spontaneous suicides and post the drug suicides. Contact email is Leigh. Henderson mhra. Hi, Perene here. Spermogram was normal, MRI to look for pituitary tumors, too.

I am looking for natural ways to increase my T and libido. Will return sooner. I have sexual dysfunction since 7 yrs when I took accutane for 6 months.

I cannot find any treatment and cannot marry. I became like a robot without any feeling after I was very horny. I am Traci. I am 32 yrs old n was also on Accutane at a young age.

My question is have u had children? Try meditating up to 1 hr every day or more if you can. Also gentle cardio exercise and hot baths daily to help your body relax.

I had a reaction to saw palmetto, a 5ar inhibitor in supplement form and had all the same issues as guys who took accutane and propecia and some ssri anti depressants.

Men and women will benefit from regular meditation in dealing with this condition. You will only know what it will do for you if you try it. Try it daily for a few months , if it works for you keep doing it. Good Luck. I was never told that accutane reduces growth hormone and testosterone levels before taking it, 2 things I really needed at the age of Derms need to stop sugar coating this poison and tell patients how dangerous accutane really is.

My son was never warned of this either. It is not even a listed side effect. It ruined my life the same way. Became impotent at age 16, 20 years old now. I have felt DEAD for 4 years now. No energy in my body, aching joints, a penis that no longer works, a brain that feels severely damaged. Go look up accutane. You learn later that this poison they give innocent children that just want their acne to go away is actually chemotherapy designed for brain cancer. I have hope though. I am on my journey to ingest cannabis oil because i have learned how extremely medicinal it is and believe it may just be the cure for all these horrible side effects.

If anyone want to talk about problem, erectile dysfunction, problems after taking accutane can do that on mail: axehector hotmail. Everything anonymously of course Regards.

Hello Ivica I took accutaine when I was a teenager and my acne was very bad. I am now 81 years old. I got married at 40 and devorsed at I had a sexless marriage ED has bothered me most of my life. If you have any words of wisdom I would appreciate them. Regards, Frank. Accutane has ruined my life. Accutane killed my penis is the best way I can describe how I feel sexually. Aside from impotence, I have very very low libido.



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